Short Answer: Yes.
Longer Answer: Depending on how you want to balance the game out (and which effects you like - I for one hate the cyber threshold rules that are in almost every system (cyberpsychosis, essence)) there will be a few things you will have to write / improvise. The most common solution is to add a "chrome" stat to the wealth rules, which means that players will have a certain amount of gear they can put into their bodies "for free".
The gadget rules are kind of akin to the prize rules, in that you can have them in whatever "housing" you want (your right hand can contain a concealed small caliber pistol, or your eye can contain a miniature videocamera). I would also crib the prize rules for things like prototypes - for example: A prototype nanite hive that increases protein synthesis and blood cell count is a prize that increases Strength and lets you drop Fatigued once a scene.
Biotech is a little harder - anything printed goes out of date pretty rapidly, so a lot will have to be improvised (at least, if I am recalling correctly, you have a Biotech background which will make this bit easier for you). So if you're not afraid to do some improv, you should be perfectly fine.
There's a handful of threads on the forums of peoples work, even without access to 2.0 it should make plenty of sense to you with your FC experience. Check out: Jtraub's Cybercraft 2.0
, A Cyborg Expert Class
, A Cyborg Talent
, and Some Campaign Qualities from FishXXIII
Bonus Question: Where you looking at putting a game together soon? I'm working on a Cyberpunk setting (watched the 2 Ghost in the Shell films in prep for the series a couple days ago myself (hadn't seen them previously either), as well as Dollhouse, Total Recall 2070 and rereading some of my favourite CP books - Neuromancer being a big one). I haven't decided which system I'm going to use, since I'm currently focused on world building (and then will work out which system has the mechanics that suit the setting best) - but it'll be either Spycraft or GURPS. If the former I will happily share any of my work if you're interested.
Hope that helps. The hardest thing about Spycraft seems to be getting the books (if you don't want a digital copy) - the guy who runs my FLGS said all his suppliers couldn't get copies for him (he was trying to sell it instead of d20 Modern).