By way of explanation on the photos, from top to bottom:
Pic 1: Left to right, the books shown are the original AEG color Spycraft 2 rulebook, the second printing of the second printing (Mongoose, B&W, lie-flat binding), and softcover print-on-demand from DTRPG/Lightning Source.
Pic 2: Tried to show the difference in the artwork, but didn't quite come out. Some of the p-o-d art is noticeably brighter or darker than that in the offset-printed version.
Pic 3: Difference in the covers, again, offset on the left, p-o-d on the right. The back cover art and text box differences are like these.
Pic 4: Chapter intro pages. The artwork on the left page is significantly darker in the p-o-d version.
Pic 5: Yep, the binding allows the book to lie flat.
Pic 6: I think this is common among p-o-d books; a couple of my Pathfinder-licensed books show this, too. There's a thin white border along a couple sides of the page, no more than an eighth of an inch. Sometimes along the side and bottom, sometimes just the side. No text or artwork is lost (yay, borders).
Pic 7: Charts are clear and easy to read.