The wife and I just started playing this after falling in love with Sentinels of the Multiverse and wanting to combine that fun with the awesome-ness that is Spycraft. We are enjoying in, though there is a bit of a learning curve. Not because the mechanics or concepts are hard to grasp, but in sorting out the intent from the wording of the rules and cards. Once you "get into the head" of the designer, there was an epiphany moment where it all just fell into place.
As with all games though, it would be nice to have a forum to discuss ambiguous rulings, builds, strategies and such. If anyone here wants to use this thread or start another, I'd watch with great interest and contribute where I can.