I'm on holidays at the moment, so I decided to replay Bioshock. I've noticed that it is almost seamless with Fantasycraft - you can map Plasmids / Tonics directly to the magic item rules with almost no thought, and just need to throw some rules together for the advanced firearms [which isn't actually that hard]. Not to mention how easy Splicers are to put together with the NPC system either.
EDIT: Also - Rep = Adam. You can spend your adam to give yourself more "tonic slots" (renown) or to buy new powers, but potentailly have to leave some behind (the prize limit of renown + 1). Makes me wanna run a system shock game when 10k bullets comes out.